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The group validated the use of the IV vitamin C for cancer therapy

doi: 10.1038/nrc3380 28 HardingSMBenciJLIriantoJDischerDEMinnAJGreenbergRA

The tissue tolerates more

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Caspase-8 is primarily activated by cell surface death receptors, such as Fas or TRAIL receptors, and its activation can further propagate the extrinsic apoptotic pathway, leading to caspase-3 activation