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also reported that the inhibition of GPX4 impaired the OT-1 T cells antigen-specific killing of cancer cells, and this effect was rescued by ferroptosis inhibitors, vitamin E and Fer-1.[46] Moreover, GPX4 has already been shown to control lipid oxidation and to support physiological T cell responses [47]

The HECT domain of full-length Nedd4-2 displays a typical bi-lobal architecture and adopts a T-shaped conformation (Supplementary Fig

doi:10.3945/jn.110.133900 Flavonols are polyphenols belonging to the flavonoid family

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The pathway for the initial glycan processing and synthesis of core N -glycans in the endoplasmic reticulum (ER) is evolutionally conserved in all eukaryotes and is essential for cell viability as part of the protein folding machinery (Nagashima et al., 2018)