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Begin by defining clear objectives and measurable endpoints (for example: receptor affinity constants, AMPK phosphorylation readout, cAMP changes by assay, or LCMS limit-of-detection)

They explained that when a patient is at CKD stage 4, they have severe kidney damage, and it is critical to slow the loss of kidney function by managing health problems, such as oral/dental infection, that directly complicate and are complicated by their kidney disease