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Therefore, enhancing the anticancer effect of immune cells by targeting the metabolic vulnerability of tumors or altering the metabolic program of immune cells to adjust to the pro-inflammatory state will be one of the approaches of cancer therapy, alone or in combination with other treatments

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Although CRCI was initially regarded as a temporary symptom, studies have shown that these symptoms persisted from 1 month to 10 years following treatment (Jim et al., 2012

These negative effects can continue into childhood and adulthood and may have multigenerational consequences

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