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Most current therapeutic candidates for NDDs face challenges in crossing the bloodbrain barrier, substantially limiting their clinical efficacy (Ross and Poirier, 2004)

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5 Basic research on the correlation between iodine and metabolism Clinical studies have demonstrated that iodine nutrition has an impact on metabolism

Acknowledgments Financial support from FCT/MCTES through national funds UID/MULTI/04378/2019 and Norte Portugal Regional Coordination and Development Commission (CCDR-N)/NORTE2020/Portugal 2020 (Norte-01-0145-FEDER-000024) and a PhD grant (SRRH/BD/139622/2018) attributed to D