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Additionally, the increase in hemichannel activation due to an increase in pro-inflammatory cytokines [e.g., tumor necrosis factor- (TNF-) and interleukin-1 (IL-1)] in primary cell cultures and mice results in an increase in the release of various ions (i.e., K + , Ca 2+ ) and gliotransmitters (i.e., ATP, glutamate) into the extracellular space, further disrupting homeostasis and possibly contributing to neuronal death (Retamal et al., 2007

98,99,100,101 A systematic meta-analysis that included 13 studies showed that the KD not only guarantees the basic supply of nutrients but also maintains a negative balance of energy, thereby decreasing the fluctuation and reduction of insulin secretion caused by reduced carbohydrate intake as well, which eventually leads to increased insulin sensitivity

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these AGEs then bind to RAGE receptors, activating NOX enzymes and generating O 2 - while triggering pro-inflammatory NF-B signaling (Yan et al., 2023)

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