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The impact of the reaction pH on activity of A

Under normal circumstances, A produced by autophagosomes is transported to lysosomes and degraded by A variety of hydrolases

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To further confirm that the autophagic cell death of GABAergic neurons was also induced by sulindac in mice, haematoxylin/eosin (H&E) staining and Nissl staining were performed and revealed that sulindac administration for 1 month also resulted in significant neuronal cell death in mice at doses of 26 mg/kg, 52 mg/kg (human equivalent dose) and 104 mg/kg (Fig