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It should be noted though, that inappropriate administration of folate when there is a vitamin B12 deficiency may cause neurologic and hematologic relapse (Reynolds, 2014)

Mice lacking CYP27B1 or VDR exhibit thymic atrophy, reduced AIRE + mTECs, impaired T cell negative selection, and gene expression profiles resembling those of aged thymic tissue [143]

These effects can potentially be achieved by both the administration of selected antioxidants such as vitamin E, vitamin C, or NAC, or after the consumption of food rich in nutraceutical compounds, which may show additive or synergistic effects

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Autism spectrum disorders and autistic traits: A decade of new twin studies