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doi: 10.1007/s11011-022-01146-7 Summary Keywords ketogenic intervention, disease-modifying therapy, Alzheimers disease, circulating biomarkers, metabolic interaction, ketogenesis, brain energy fuel Citation Ramezani M, Fernando M, Eslick S, Asih PR, Shadfar S, Bandara EMS, Hillebrandt H, Meghwar S, Shahriari M, Chatterjee P, Thota R, Dias CB, Garg ML and Martins RN (2023) Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimers disease

We investigated their effects on cell proliferation by WST-8, apoptosis by Caspase-3/7 activity, sphere formation, and tumour formation as well as signalling pathways regulating these phenotypes

Finally, melatonin partially prevented the alterations at the subunit level of respiratory complexes III and V and significantly reduced the expression of complex I subunit NDUFB8 in heart mitochondria of the treated animals, thus inhibiting ROS generation