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Animal information Animal experiments were approved by the University of Houston Institutional Animal Care and Use Committee and adhered to the recommendations in the NIH Guide for the Care and Use of Laboratory Animals and to those from the Association for Research in Vision and Ophthalmology

has shown that intranasal administration of ferritinase inhibitors, ferritinase-1 and lipoproteinase-1, immediately after cerebral ischemia in mice reduced neuronal damage, and the protective effect continued until 6 h after reperfusion (Tuo et al