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Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity

demonstrated that a new chemical entity termed ANG1005 developed by conjugation between targeting peptide angiopep-2 (19-amino acid peptide obtained from Kunitz domain of LRP1 ligands having affinity to LRP1 and efficiently bypasses the BBB through LRP-1 mediated transcytosis) to high molecular weight anti-HER2 mAb to amplify their uptake through BBB (i.e

The mechanism of bilateral amblyopia is thought to be related to failure of both eyes to achieve a clear foveal image resulting in abnormal development of the visual cortex bilaterally

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Finally, there is the evidence of BPC 157 generation of NO in ex vivo condition (Sikiric et al., 1997a