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This can be achieved by using PD-1 blockade antibodies or modified CAR-T cells that secrete PD-1 blockade single-chain variable fragments (scFv) in PD-L1+ hematological and solid tumor clinically relevant syngeneic and xenograft mouse models (179), which can increase glucose concentration in TME to favor T cell glycolysis and the production of IFN- ( Figure 1 )

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Your doctor or healthcare provider may not know anything about taurine, Zumpano notes, but you can find a practitioner or registered dietitian that does, or ask your current provider to help you navigate the information and determine whether its the right choice for you. While Zumpano isnt in the habit of recommending taurine supplements, there are some basic changes you can make to your diet that could, potentially, have a similar effect