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Data are reported as means.e.m

These neuronal activation patterns are attenuated or absent in RAMP1/RAMP3 knockout animals, further implicating AMYR and AMYR as the functional receptors mediating these central effects

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Agents counteracting the redundant functioning of pro-angiogenic pathways and growth factors, patrolling the conspiracy of BMD tumor and stromal cells including pericytes and CSCs, antagonizing the angiogenesis-independent alternative mechanisms of vascular remodeling and overcoming the rebounds of invasiveness and metastasis after drug holidays should be an integral part of a judiciously formulated combinatorial therapeutic approach of future anti-angiogenic settings