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Institutional review board statement The study was conducted in compliance with the Declaration of Helsinki, and was reviewed and approved by the Ethics Committee of University of Rome Tor Vergata (Registration Number: 141/20, July 23, 2020)

It is supplied as a semi-dry powder (1 g of powder gives ~3.3 ml final drained medium) to significantly shorten conditioning time before ligand coupling

The dose modification factor for tetraplatin after BSO treatment was similar to that observed for melphalan in all three cell lines

Plotting the coulombic, van der Waals (vdW), and total energies versus time (Fig

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