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NeuenBLHeerspinkHJLVartPClaggettBLFletcherRAArnottCet al

CSCs unique properties, such as self-renewal and differentiation potential, upregulated surface membrane immune inhibitory ligands and release of various chemo/cytokines collectively contribute to therapy resistance and pose significant challenges in achieving long-term remission [398, 399]

In terms of dosage, amounts as low as 50 mg have been found to reduce fatigue, with 680 mg being the suggested upper limit, due to a bell-curve effect

Improvement was noted at each of four evaluations, and lasting improvement was attributed to the biofeedback portion of treatment program

doi: 10.1038/nature08097 21 PearceELPoffenbergerMCChangC-HJonesRG