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10.7150/ijbs.57825 188 WuD.WangX.ZhouR.YangL.CederbaumA

SAG has demonstrated efficacy in replenishing intracellular GSH in cultured fibroblasts from patients with genetic glutathione synthetase deficiency a condition where the de novo synthesis pathway is non-functional

Collectively, this study and others that are conducted with this global team of experts focused on unraveling the biological mechanisms of konzo operates at the highest standards of inclusion, ethical considerations, participant safety and authorship, with the goal of bringing global attention to konzo and other neglected diseases that burden the worlds most impoverished populations

doi: 10.1016/j.biomaterials.2013.02.002

Brain tissues were rinsed with ice cold PBS (pH 7.4) to remove the excess blood thoroughly and weighed before homogenization