glutathione regulation of synthesis Glutathione Participation in the Prevention

34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids . Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years

Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice

IUBMB Life 75:811829

The emerging role of long noncoding RNA in depression and its implications in diagnostics and therapeutic responses

[3] Two of these are in the citric acid cycle through which many organisms turn nutrients into energy