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A previous study supported this, showing that treatment of SLC1A5 -knockdown HNSCC cell lines with V-9302 led to marked inhibition of glutamine metabolism, thereby suppressing growth and proliferation both in vitro and in vivo 97

Interestingly, host T cell immune response was needed to inhibit HO-1 by SnPPIX, and SnPPIX failed to reduce bacterial growth and activity of Mtb HO-1 enzyme in broth culture (192)

It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive

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