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Cycles often run 8-12 weeks with breaks between

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[5] [8] [12] When the need for ribose 5-phosphate is much greater than that for NADPH When significantly more ribose 5-phosphate than NADPH is required, as in rapidly dividing cells with high rates of nucleotide synthesis, precursors of DNA, the oxidative phase of the pentose phosphate pathway is bypassed , and NADPH is not produced