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Disruption of the uORF using a CRISPR-Cas9 approach removed the AsA feedback repression of GGP and increased AsA content in tomato fruit up to the remarkable amount of 1 mg per gram fresh weight ( Actinidia eriantha (AceMYBS1 and AceGBF3) working synergistically to activate GGP have been recently described by Wolucka et al

If you are not improving with this approach, then the next step maybe a course of shockwave therapy

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