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At least 99% of AREs have now been proposed to be degenerate, with degenerate motifs associated negatively with transcriptional outcome and half sites more strongly influenced by transcription factors acting through adjacent motifs or cooperating factors [56]

At present, some drugs containing saponins or total saponin extracts are used for clinical cancer patients in the Chinese pharmaceutical market

However, in subsequent investigations in rodent models of depression, (2R,6R)-hydroxynorketamine did not exhibit antidepressant-like effects and increased aggressive behavior (Yang et al., 2019)

167 The breast cancer cells can engulf exosomes secreted by senescent neutrophils, thereby enhancing their resistance to chemotherapy

A total of 28 metabolites were found to be significant features for further analyses based on a log2 fold change cutoff of 1.5 at 10% false-discovery rate (Figure 1A