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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

This is why Vitamin B12 therapy can be so helpful: By getting an intramuscular injection of B12, you can bypass the GI tract and allow for up to 100% absorption into the body and straight into your cells

According to a study published in PubMed Central (NIH), IV administration of vitamin B12 provides a faster increase in B12 levels compared to oral supplementation, making it a potentially better option for patients with severe deficiency

That is the adequate intake for most healthy adults