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A break ensures the endocrine system stays resilient and avoids long-term suppression

Free iron is reactive and dangerous to cells, and NRF2 regulates the expression of ferritin heavy and light chains (FTL and FTH1), which immediately bind free iron, as well as ferroportin, which exports it [79]

Alpha-synuclein, the primary component of Lewy bodies, is prone to oxidative modifications, which can promote its aggregation and toxicity

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In DKD, an imbalance between protein synthesis and degradation leads to protein accumulation, which exacerbates glomerular hypertrophy and further renal damage, thereby promoting the development of DKD (Zhang Z