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Interestingly, the screening revealed the existence of an allosteric pocket close to the NADPH binding site, named the doorstop pocket since ligands binding at this site interfere with TR activity by hampering the opening movement needed to allow cofactor binding

Data Availability The datasets generated during the current study are available from the corresponding author on reasonable request

438 Exosomes are formed through the inward budding of the endosomal membrane, resulting in the pinching off and release of intraluminal vesicles (ILVs) inside endosomes

A pilot study of cerebral dialysate from 26 ICU patients with TBI defined two clinically relevant metabolic states based on distinct changes in glucose, lactate and pyruvate as well as metabolites related to ketone metabolism [46]