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In hypoxic HUVECs, eNOS Ser1177 phosphorylation was shown to be reduced, whereas Thr495 phosphorylation was increased, resulting in altered eNOS activity and reduced NO production [148]

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It remains to be clarified whether eosinophil plasticity or heterogeneity underlies the apparent ability of these cells to contribute to mucosal tissue homeostasis during the steady state, versus their proposed pathological role in disease states such as asthma, EoE 1 , and colitis