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It also prevents the migration and adhesion of RPE cells involved in the formation of epiretinal membranes in AMD, through inhibition of PDGF-beta receptor activity and downstream signaling pathways [90]

Biol: CB 24 , R453R462 (2014)

In vitro studies provide further mechanistic insight, showing that lithium enhances mitochondrial function, supports oxidative balance, and prevents apoptosis through mechanisms involving cytochrome c regulation, Bcl-2 modulation, and preservation of complex I activity

Its appeal comes from stability and breadth: BPC-157 stays intact in gastric acid, where most growth-factor peptides break down, and animal studies link it to repair across skin, muscle, tendon, ligament, bone, nerve and the gastrointestinal tract

Hum Mol Genet 14: 22012208