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Normal aging shares several features with AGHD syndrome, including reduced muscle and bone mass, increased visceral fat, reduced exercise and cardiac capacity, atherogenic lipid profile changes, thinning skin, and various psychological and cognitive issues (24-25) (Table 1)

At baseline, GRMET, TYRMET, and KYNURIC partial correlations were most impacted, while at week 8, KYNHVA, KYN3OHKY, 5HTP-G, and HGAGR values were most impacted by HRSD 17 week 8 status (Fig

These observations are exploratory and not conclusive

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