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The understanding of this mechanism was later derived from a separate study involving mice.

The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid

346,347,348 The first is the exogenous route, in which the NADs are directly introduced into the obtained exosomes via electroporation, co-incubation, sonication, extrusion, and freeze-thaw cycling

PMID: 10501046

doi: 10.1007/s12551-020-00726-0 89 WangQMaLAnCWiseSGBaoS