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found that AS intervention group exhibited a significant increase in intestinal microbial diversity (primarily Lactobacillus ), compared to the cirrhosis model group, and resulted in a deceased incidence and quantity of BT, contributing to the protection of the intestinal barrier, reduction of inflammation, and mitigation of liver injury

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As such, it is estimated that 60 million Americans consume APAP on a weekly basis ( Acetaminophen hepatotoxicity is characterized by acute liver failure, centrilobular hepatic necrosis, renal tubular necrosis and hypoglycemic coma (Lancaster et al., 2015), an outcome that can be more frequent with the use of APAP at doses above the therapeutic range

To overcome these challenges, future research should prioritize large-scale, multicentre, and multifactorial randomised clinical trials