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doi: 10.1177/153537020422900506 44 SandersonJTBoermaJLansbergenGWAvan den BergM

During the pre-diabetes stage, BB rats that are diabetes prone have increased intestinal permeability, altered tight junction proteins (specifically claudin 7), increased gut infiltration by neutrophils and decreased numbers of gut natural killer cells in comparison to BB rats which were diabetes resistant [168, 178]