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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

Furthermore, CYP-generated eicosanoids likely are involved in more diverse physiological responses than previously appreciated

3x Glutathione

[24] and Thomas et al

Another aspect of the present invention embraces a method of screening for a compound that is capable of modulating the biological activity of a HGPRBMY14 polypeptide, comprising providing a host cell containing an expression vector harboring a nucleic acid sequence encoding a HGPRBMY14 polypeptide, or a functional peptide or portion thereof (e.g., SEQ ID NOS:2)