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Ethical approval was obtained from the relevant institutional review boards at participating sites, and all patients provided written informed consent in accordance with local requirements

Food-derived glutathione was present in rat intestines and livers (approximately 60 and 300 mol/kg, respectively, 120 min after ingestion) in electrochemically reduced form, while all food-derived glutathione in the blood plasma was conjugated with proteins and low-molecular-weight thiol compounds

Effective results have been reported with daily doses ranging from 0.5-2 grams a day

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