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Consistently with a role in fibroblast activation, an amelioration of tissue fibrosis was observed in TLR4 knockout in murine models of systemic sclerosis [131]

MOTS-c stands out for its role in metabolic homeostasis , positioning it as a candidate for both performance enhancement and age-related disease prevention

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The over-expressed P-gp could increase the negative charge on the MDR tumor cell membrane, thus enhancing AMP binding by electrostatic attraction