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J Am Acad Child Adolesc Psychiatry 57:867875

By employing network pharmacology modeling and broad counter-screening early on, developers can manage polypharmacologyleveraging it to enhance efficacy (through synergistic target engagement) and using informatics to avoid trap compounds that bind irrelevant or harmful targets

Metal Chelation Carboxyl and hydroxyl groups can chelate metal ions, forming stable complexes

Another commenter stated that CMS must ensure reimbursement rates are sufficient to enable providers to adopt high-value applications of software-based technologies