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TQ by suppressing pro-inflammatory cytokines, interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-), as well as interferon-gamma (IFN-), and interleukin-6 (IL-6), mitigates disease severity

The consequences of reactive astrogliosis and microglial activation following SARS-CoV-2 infection can initiate a cascade of aberrant signalling events, potentially leading to excitotoxicity which represents a pathological process with deleterious consequences [15, 35]

However, in AD, tau becomes hyperphosphorylated to detach from microtubules and form toxic neurofibrillary tangles that impair cellular transport and accelerate neuronal death (Ye et al., 2025)

JAK/STAT inhibitors can provide additional therapeutic options for patients with NIU

The resulting useful particles were then used for automatic particle picking using Topaz (55)