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These results suggest improvement in insulin sensitivity, and moreover, no additional side effects to those found with placebo were observed in T1D, meanwhile in T2D patients oedema, jaw pain and arthralgias were 4 % lower than previous reports [276, 277]

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demonstrated in enteric glial cell models that PS-NPs accelerate the aggregation of mutant A53T -synuclein, disrupt mitochondrial membrane integrity, and impair lysosomal function, collectively exacerbating dysregulation of the mitochondrial-lysosomal axis 41

Nevertheless, in some cell types or cell lines, the inhibition of GPX4 cannot induce ferroptosis, suggesting the presence of alternative mechanisms distinct from GSH-dependent pathways (70)

Jovanovic D, Ceriman-Krstic V, Kabalak PA, Viola L, Papatheodosiou K