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[5] Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X chromosome in certain cells creates a population of G6PD-deficient red blood cells coexisting with unaffected red blood cells

None of that makes them useless

Moreover, scavenging receptor D6 plays a role in this process by suppressing the binding of inflammatory chemokines to LEC surfaces

No study explained whether the distribution of groups and the analysis of results were done blindly, so we considered a high risk of bias