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Copper itself is a comparatively weak skin sensitizer a 2014 review (PMID 25098945) reported positive copper patch-test reactions in roughly 3.8% of tested subjects so contact allergy is possible but uncommon

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Although uncommon, it is possible to have elevated B12 levels in a blood test, says Sheri Vettel, a registered dietitian nutritionist (RDN) with the Institute for Integrative Nutrition

More specifically, IGF-1 mediates its anabolic effects such as growth, development, and recovery in each of your tissues