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It also promotes the expression of proteins related to disulfide bond formation and molecular chaperones and proteins involved in ER degradation and vesicle transport ( via the inhibition of BCL-2 protein family ( Since protein synthesis and oxygen-dependent protein folding are energy-intensive processes, and hypoxia significantly reduces the level of intracellular ATP, regulating mRNA translation is an important cellular response to hypoxia (72)

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Furthermore, there was a significant correlation in both markers used in tumour areas (Extended Data Fig

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