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Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter

Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)

These advances allow researchers not only to examine the entire TME but also to investigate specific cell subtypes within it

Heyworth, P

Moreover, interventions targeting oxidative stress, informed by 8-OHdG levels, could hold promise in mitigating IBD progression