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Description

Structural comparisons of the substrate-binding site between the substrate-free dmDAT (light cyan, PDB ID: 6M0F) and MIBG-bound hNET (light blue)

DermatologyUlrichMKrueger-corcoranDRoewert-huberJSterryWStockflethEAstnerS201022011524 74

Animal model methodology Female Wistar rats were randomly assigned to five groups: control, Dox, Dox + EMPA, Dox + TRF, and Dox + EMPA + TRF, n = 5 animals per group

In the aversive context test, kefir-fed mice showed markedly lower fear responses, with 76% fewer freezing episodes (p = 0.03) on day 2% and 91% fewer on day 7 (p = 0.02) compared to control mice (Figures 4A,B), indicating sustained attenuation of fear-related responses