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Beck and colleagues reported in 2014 that the 117-patient proof-of-concept study found ipamorelin well tolerated but did not reach statistical significance on its primary composite gastrointestinal endpoint at the studied dose

10.1016/j.bbagen.2018.06.003 18 BianJ.CaiF.ChenH.TangZ.XiK.TangJ.et al (2021)

Here is an article that gets into this in more detail...and my colleague Yang Hu just published a full strategic briefing that dives into this topic which is available to subscribers (or available for purchase)

In sum, ferroptosis represents a paradigm shift in cancer therapy, offering a unique mechanism to target resistant tumours through lipid peroxidation-induced cell death

To address the interplay between ROS and antioxidants in cancer chemoresistance, novel therapeutic strategies aim to manipulate redox homeostasis to enhance chemotherapy efficacy