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Description

This study identifies loss of LKB1 in KRAS* lung cancer results in an increased dependency on the hexosamine biosynthesis pathway, providing a prime example for how co-occurring mutations cooperate with KRAS* to direct metabolism

Methylglyoxal, glyoxal, and their detoxification in Alzheimers Disease

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Crosstalk between Nrf2 and ferroptosis As an important stress factor that maintains intracellular oxidative homoeostasis, Nrf2 controls the expression of many antioxidant genes