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194 CoQ10 may be synergistic with curcumin, as one study ( n = 100) found that a combination of curcumin (80 mg) plus CoQ10 (300 mg) was significantly more effective than either therapy alone for migraine prevention

10.1038/sj.jid.5700340 13 BirleaS.CostinG.-E.NorrisD

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Topiramate additionally requires precaution in women of childbearing potential as topiramate is associated with oral clefts if used during early pregnancy

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