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Natural pectin, found in the peel and pulp of citrus fruits, is a large, complex carbohydrate molecule that passes through the human digestive tract unabsorbed, acting merely as dietary fiber

Hassler J, Cao SS, Kaufman RJ (2012) IRE1, a double-edged sword in pre-miRNA slicing and cell death

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In summary, while the reviewed clinical studies provide encouraging signals, they suffer from small samples, heterogeneous populations, non-standardized endpoints, and short durations