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The ethanol extract at 200 and 400 mg/kg could strongly decrease IL-1, cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), and myeloperoxidase (MPO) serum levels compared to the control group not provided with the extract ( in vivo inhibition of Th2-cell-driven response to the allergen

doi: 10.2165/11631880-000000000-00000

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Preliminary results from a study conducted with pregnant beef cows in late gestation reported increased maternal plasma MET concentrations in cows fed RPM and lower concentrations in those supplemented with GAA, with intermediate values in cows receiving both RPM + GAA (Motta et al., 2025), highlighting the role of GAA as a methyl consumer

Current research is focused on targeting inflammasomes, glial signaling, and regulated cell death as strategies to mitigate neurodegeneration [156]