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It creates a permanent upstream bottleneck that compounds existing enzyme-level impairments in glutathione production

However, milk thistle has mild CYP3A4 interactions, and any supplementation should be discussed with your provider, especially if you take other medications or have liver disease

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doi: 10.1016/j.immuni.2015.05.024 18 RayJPStaronMMShyerJAHoP-CMarshallH-DGraySMet al

Combining curcumin with established anti-fibrotic drugs in a single nano-formulation could also create powerful synergistic therapies, where curcumin acts as a sensitizing agent to enhance the primary drugs efficacy