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In animal experiments, copper ions binding to GSH caused intracellular GSH depletion, impairing antioxidant capacity, exacerbating oxidative stress and protein nitration, and leading to neuronal damage (8)

And then, yes, we need more human clinical data

Additionally, SIRT1 modulates the activity of forkhead box O (FOXO) transcription factors, which activate the expression of enzymes involved in ROS detoxification, including SOD2 (superoxide dismutase 2) and catalase, thereby attenuating oxidative stress-induced apoptosis [51]

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For instance, the total quantity of flavonoids dropped when bagged green tea was extracted with hot water (80C) for over 15 min (Dai et al., Tea samples and solvents have a large contact area because smaller particle diameters and greater specific areas are correlated