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This dynamic nature of TGF-s involvement implies that the timing of therapeutic intervention is critical

The 1.7mg dose was not part of the original STEP trial protocol for semaglutide 2.4mg (which used 0.25, 0.5, 1.0, 1.7, then 2.4), but it serves as a crucial intermediate step that reduces the jump between 1.0mg and 2.4mg