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To address these questions mentioned above, the primary aims of this study were to investigate the effects of metformin on NSCs activation and ferroptosis both in vitro and in vivo, and to determine whether these effects are mediated by canonical AMPK-dependent regulation

Plasma steroid concentrations in male rhesus monkeys following treatment with the P450c17 (CYP17) inhibitors VT-464 and abiraterone acetate: a comparison to human 17,20-Lyase (lyase) and combined lyase/17-hydroxylase (hydroxylase) deficiencies [abstract]

From clinical translation, the safety and efficacy data of LBNP-PC@M demonstrated substantial translational potential

It is a heme-containing enzyme that produces O2 from H2O2 It reduces H2O2 and organic hydroperoxides using GSH and requires selenium It converts superoxide into hydrogen peroxide without cofactors It oxidizes GSSG to GSH using NAD+ Correct Answer: It reduces H2O2 and organic hydroperoxides using GSH and requires selenium Q5